Article

Rapid Autopsy Multi-Omic Analysis Identifies Divergent Evolutionary Trajectories and DNA Damage Resistance Mechanisms in FGFR2-Driven Cholangiocarcinoma

2025-12-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Intrahepatic cholangiocarcinoma (iCCA) is an aggressive cancer with poor prognosis. Fibroblast Growth Factor Receptor 2 (FGFR2) alterations, including gene fusions and gain-of-function mutations, occur in ∼10% of iCCA and lead to active FGFR2 signaling. Targeted therapy with an FGFR inhibitor (FGFRi) indeed improves survival, however nearly all patients eventually become res...

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Literature Corpus work: f4d76204-3528-5ee7-94c4-7c9b113f02e4
DOI: 10.64898/2025.11.25.25340882

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