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Article

Influence of CYP3A5 genetic differences in tacrolimus on quantitative interstitial fibrosis and long-term graft function in kidney transplant recipients.

International immunopharmacology - 1 May 2018

Komine Naoki, Satoh Shigeru, Saito Mitsuru, Numakura Kazuyuki, Inoue Takamitsu, Tsuruta Hiroshi, Narita Shintaro, Komatsuda Atsushi, Nanjo Hiroshi, Kagaya Hideaki, Niioka Takenori, Miura Masatomo, Mitobe Yoko, Habuchi Tomonori

Abstract excerpt

The impact of CYP3A5 polymorphisms on clinical outcomes is controversial. The present study investigated the impact of CYP3A5 genetic differences on the development of interstitial fibrosis (IF) from 0 h to 1 year post-transplantation in biopsy sections from 96 living kidney recipients under the same target trough regimen of tacrolimus. The relationships between CYP3A5 polymorphisms and long-term graft function...

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Share to Cytochrome P-450 CYP3A
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

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Share to Postoperative Complications

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Source

Identifiers

PMID: 29550576
DOI: 10.1016/j.intimp.2018.03.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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