Article
Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients.
International journal of molecular sciences - 16 Mar 2018
Kagaya Hideaki, Niioka Takenori, Saito Mitsuru, Inoue Takamitsu, Numakura Kazuyuki, Yamamoto Ryohei, Akamine Yumiko, Habuchi Tomonori, Satoh Shigeru, Miura Masatomo
Abstract excerpt
While tacrolimus and everolimus have common metabolic pathways through CYP3A4/5, tacrolimus is metabolized solely by CYP3A4 in recipients with the CYP3A5*3/*3. The purpose of this study was to evaluate how the area under the blood concentration-time curves (AUC) of tacrolimus could be predicted based on CYP3A5 genotype and the AUC of everolimus in renal transplant patients taking both drugs. The dose-adjusted AUC...
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