Article
Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine.
Drug metabolism and pharmacokinetics - 1 Jan 2013
Zuo Xiao-cong, Zhou Ya-nan, Zhang Bi-kui, Yang Guo-ping, Cheng Ze-neng, Yuan Hong, Ouyang Dong-sheng, Liu Shi-kun, Barrett Jeffrey S, Li Pei-jiong, Liu Zhi, Tan Hong-yi, Guo Ren, Zhou Ling-yun, Xie Yue-liang, Li Zuo-jun, Li Jing, Wang Chun-jiang, Wang Jiang-lin
Abstract excerpt
The objective of this study was to evaluate the effect of the CYP3A5*3 allele on the pharmacokinetics of tacrolimus and amlodipine, and drug-drug interactions between them in healthy subjects. Pharmacokinetic drug interactions between tacrolimus and amlodipine were evaluated in a randomized, 3-period, 6-sequence crossover study in healthy Chinese volunteers according to CYP3A5 genotype. A single-dose and...
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