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Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency.

Development (Cambridge, England) - 15 Mar 2018

Dawson Emily P, Lanza Denise G, Webster Nicholas J, Benton Susan M, Suetake Isao, Heaney Jason D

Abstract excerpt

Testicular teratomas result from anomalies in embryonic germ cell development. In 129 inbred mice, teratoma initiation coincides with germ cell sex-specific differentiation and the mitotic-meiotic switch: XX and XY germ cells repress pluripotency, XX germ cells initiate meiosis, and XY germ cells activate male-specific differentiation and mitotic arrest. Here, we report that expression of Nanos2, a gene that is...

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Cell Culture Techniques
Embryonal Carcinoma Stem Cells
Mice, 129 Strain
Real-Time Polymerase Chain Reaction
RNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Determination Processes

Testicular Neoplasms

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Identifiers

PMID: 29545285
DOI: 10.1242/dev.156612
PMCID: PMC6514421

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