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Article

Endogenous Nodal signaling regulates germ cell potency during mammalian testis development

4 Oct 2012

Abstract excerpt

Germ cells, the embryonic precursors of sperm or oocytes, respond to molecular cues that regulate their sex-specific development in the fetal gonads. In males in particular, the balance between continued proliferation and cell fate commitment is crucial: defects in proliferation result in insufficient spermatogonial stem cells for fertility, but escape from commitment and prolonged pluripotency can cause...

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PMID: 23034635
DOI: 10.1242/dev.083006

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