Article
Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Apr 2019
Kim So-Young, Jones Drew R, Kang Ji-Yeon, Yun Chul-Ho, Miller Grover P
Abstract excerpt
Coumadin (R/S-warfarin) metabolism plays a critical role in patient response to anticoagulant therapy. Several cytochrome P450s oxidize warfarin into R/S-6-, 7-, 8-, 10, and 4'-hydroxywarfarin that can undergo subsequent glucuronidation by UDP-glucuronosyltransferases (UGTs); however, current studies on recombinant UGTs cannot be adequately extrapolated to microsomal glucuronidation capacities for the liver....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.