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Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2005

Bauman Jonathan N, Goosen Theunis C, Tugnait Meera, Peterkin Vincent, Hurst Susan I, Menning Lee C, Milad Mark, Court Michael H, Williams J Andrew

Abstract excerpt

The predominant metabolic pathway of gemcabene in humans is glucuronidation. The principal human UDP-glucuronosyltransferases (UGTs) involved in the glucuronidation of gemcabene were determined in this study. Glucuronidation of gemcabene was catalyzed by recombinant UGT1A3, recombinant UGT2B7, and recombinant UGT2B17, as well as by human liver microsomes (HLM). Gemcabene glucuronidation in recombinant UGTs and...

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Identifiers

PMID: 15980101
DOI: 10.1124/dmd.105.005108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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