Article
Assays and applications in warfarin metabolism: what we know, how we know it and what we need to know.
Expert opinion on drug metabolism & toxicology - 1 Jul 2011
Jones Drew R, Miller Grover P
Abstract excerpt
INTRODUCTION: Coumadin (R/S-warfarin) is the most widely prescribed oral anticoagulant in the world; nevertheless, its clinical use is complicated by unpredictability in dose requirements to achieve and maintain optimal anticoagulation. Variations in warfarin metabolism among patients contribute to unpredictability in therapeutic responses. Studying the clinical relevance of warfarin metabolism poses a...
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