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Article

Identification of human UGT isoforms responsible for glucuronidation of efavirenz and its three hydroxy metabolites

14 Feb 2011

Abstract excerpt

Uridine 5'-diphosphate-glucuronosyltransferases (UGTs) involved in the glucuronide formation of efavirenz (EFV) and its three hydroxy metabolites, 8-hydroxyefavirenz (8-OH EFV), 7-hydroxyefavirenz (7-OH EFV), and 8,14-dihydroxyefavirenz (8,14-diOH EFV), were assessed. Among 12 recombinant UGT isoforms tested, only UGT2B7 showed catalytic activity in the formation of EFV-N-glucuronide (EFV-G) as previously...

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Identifiers

PMID: 21319958
DOI: 10.3109/00498254.2011.551849

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