Article
Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2011
Miners John O, Bowalgaha Kushari, Elliot David J, Baranczewski Pawel, Knights Kathleen M
Abstract excerpt
Enzyme selective inhibitors represent the most valuable experimental tool for reaction phenotyping. However, only a limited number of UDP-glucuronosyltransferase (UGT) enzyme-selective inhibitors have been identified to date. This study characterized the UGT enzyme selectivity of niflumic acid (N...
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