Article
Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth.
Diabetes care - 1 May 2022
Oram Richard A, Sharp Seth A, Pihoker Catherine, Ferrat Lauric, Imperatore Giuseppina, Williams Adrienne, Redondo Maria J, Wagenknecht Lynne, Dolan Lawrence M, Lawrence Jean M, Weedon Michael N, D'Agostino Ralph, Hagopian William A, Divers Jasmin, Dabelea Dana
Abstract excerpt
OBJECTIVE: Genetic risk scores (GRS) aid classification of diabetes type in White European adult populations. We aimed to assess the utility of GRS in the classification of diabetes type among racially/ethnically diverse youth in the U.S. RESEARCH DESIGN AND METHODS: We generated type 1 diabetes (T1D)- and type 2 diabetes (T2D)-specific GRS in 2,045 individuals from the SEARCH for Diabetes in Youth study. We...
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