Article
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.
The Journal of biological chemistry - 4 May 2018
Cherian Mathew A, Olson Sydney, Sundaramoorthi Hemalatha, Cates Kitra, Cheng Xiaogang, Harding John, Martens Andrew, Challen Grant A, Tyagi Manoj, Ratner Lee, Rauch Daniel
Abstract excerpt
The human T-cell leukemia virus-1 (HTLV-1) oncoprotein Tax drives cell proliferation and resistance to apoptosis early in the pathogenesis of adult T-cell leukemia (ATL). Subsequently, probably as a result of specific immunoediting, Tax expression is down-regulated and functionally replaced by somatic driver mutations of the host genome. Both amplification and point mutations of interferon regulatory factor 4...
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