Whole-genome landscape of adult T-cell leukemia/lymphoma.

doi:10.1182/blood.2021013568

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Article

Whole-genome landscape of adult T-cell leukemia/lymphoma.

Blood - 17 Feb 2022

Kogure Yasunori, Kameda Takuro, Koya Junji, Yoshimitsu Makoto, Nosaka Kisato, Yasunaga Jun-Ichirou, Imaizumi Yoshitaka, Watanabe Mizuki, Saito Yuki, Ito Yuta, McClure Marni B, Tabata Mariko, Shingaki Sumito, Yoshifuji Kota, Chiba Kenichi, Okada Ai, Kakiuchi Nobuyuki, Nannya Yasuhito, Kamiunten Ayako, Tahira Yuki, Akizuki Keiichi, Sekine Masaaki, Shide Kotaro, Hidaka Tomonori, Kubuki Yoko, Kitanaka Akira, Hidaka Michihiro, Nakano Nobuaki, Utsunomiya Atae, Sica R Alejandro, Acuna-Villaorduna Ana, Janakiram Murali, Shah Urvi, Ramos Juan Carlos, Shibata Tatsuhiro, Takeuchi Kengo, Takaori-Kondo Akifumi, Miyazaki Yasushi, Matsuoka Masao, Ishitsuka Kenji, Shiraishi Yuichi, Miyano Satoru, Ogawa Seishi, Ye B Hilda, Shimoda Kazuya, Kataoka Keisuke

Abstract excerpt

Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasm immunophenotypically resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we performed whole-genome sequencing (WGS) of 150 ATL cases to reveal the overarching landscape of genetic alterations in ATL. We discovered frequent (33%) loss-of-function alterations preferentially targeting the CIC long isoform, which were...

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PMID: 34695199
DOI: 10.1182/blood.2021013568
PMCID: PMC8854674

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