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Article

The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4K59R mutation.

Protein science : a publication of the Protein Society - 1 Apr 2022

Sundararaj Srinivasan, Seneviratne Sandali, Williams Simon J, Enders Anselm, Casarotto Marco G

Abstract excerpt

Interferon regulatory factor 4 (IRF4) is an essential regulator in the development of many immune cells, including B- and T-cells and has been implicated directly in numerous hematological malignancies, including adult T-cell leukemia/lymphoma (ATLL). Recently, an activating mutation in the DNA-binding domain of IRF4 (IRF4K59R ) was found as a recurrent somatic mutation in ATLL patients. However, it remains...

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PMID: 34913532
DOI: 10.1002/pro.4260
PMCID: PMC8927869

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