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Article

The oncogenic role of GASC1 in chemically induced mouse skin cancer.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2015

Ozaki Yumi, Fujiwara Kyoko, Ikeda Maki, Ozaki Toshinori, Terui Tadashi, Soma Masayoshi, Inazawa Johji, Nagase Hiroki

Abstract excerpt

Gene amplified in squamous cell carcinoma (SCC) 1 (GASC1), also known as KDM4C/JMJD2C, encodes a histone demethylase that specifically demethylates lysine residues (H3K9, H3K36, and H1.4K26) and plays a crucial role in the regulation of gene expression as well as in heterochromatin formation. GASC1 is located at human chromosome 9p23-24, where frequent genomic amplification is observed in human esophageal cancer,...

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PMID: 26248577
DOI: 10.1007/s00335-015-9592-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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