Article
Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Apr 2019
Graetz Christiane, Gröger Adriane, Luessi Felix, Salmen Anke, Zöller Daniela, Schultz Janine, Siller Nelly, Fleischer Vinzenz, Bellenberg Barbara, Berthele Achim, Biberacher Viola, Havla Joachim, Hecker Michael, Hohlfeld Reinhard, Infante-Duarte Carmen, Kirschke Jan S, Kümpfel Tania, Linker Ralf, Paul Friedemann, Pfeuffer Steffen, Sämann Philipp, Toenges Gerrit, Weber Frank, Zettl Uwe K, Jahn-Eimermacher Antje, Antony Gisela, Groppa Sergiu, Wiendl Heinz, Hemmer Bernhard, Mühlau Mark, Lukas Carsten, Gold Ralf, Lill Christina M, Zipp Frauke
Abstract excerpt
BACKGROUND: The course of multiple sclerosis (MS) shows substantial inter-individual variability. The underlying determinants of disease severity likely involve genetic and environmental factors. OBJECTIVE: The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course. METHODS: Untreated patients ( n = 263) with a recent...
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