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Article

Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants.

Chemical communications (Cambridge, England) - 27 Mar 2018

Hu Shichao, Li Na, Liu Feng

Abstract excerpt

We present a novel strategy for the discrimination of single nucleotide variants (SNVs) by combining cooperativity with sequestration, which displays remarkably high specificity (discrimination factors ranging from 67 to 618 with a median of 194) against 12 model SNVs and can be easily integrated with PCR amplification to detect KRAS G12D mutation.

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Share to Base Pair Mismatch
Share to KRAS gene
Share to Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 29528359
DOI: 10.1039/c8cc00838h

Genes

KRAS

Variants

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