Article

Structural and Energetic Determinants of Monobody Recognition of Oncogenic KRAS Variants

2026-07-10

Abstract excerpt

Monobodies are engineered binding proteins that recognize extended protein surfaces and offer advantages over small-molecule inhibitors for targeting challenging KRAS oncoproteins. Monobody 12D4 exhibits high affinity and selectivity for the oncogenic KRAS(G12D) mutant, but the molecular determinants governing its recognition and the basis for its mutant selectivity remain poorly understood. Here, we combined mole...

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Literature Corpus work: b4cf70b9-afc8-59fb-8f42-d3aaf433d293
DOI: 10.64898/2026.07.09.737552

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