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Article

Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment.

Journal of cellular physiology - 1 Apr 2019

Kain Vasundhara, Halade Ganesh V

Abstract excerpt

Bioactive lipid mediators derived from n-3 and n-6 fatty acids are known to modulate leukocytes. Metabolic transformation of essential fatty acids to endogenous bioactive molecules plays a major role in human health. Here we tested the potential of substrates; linoleic acid (LA) and docosahexaenoic acid (DHA) and their bioactive products; resolvin D1 (RvD1) and 12- S-hydroxyeicosatetraenoic acids (HETE) to...

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Identifiers

PMID: 30191990
DOI: 10.1002/jcp.27165
PMCID: PMC6317995

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