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Article

Redundant regulation of localization and protein stability of DmPar3.

Cellular and molecular life sciences : CMLS - 1 Sept 2018

Kullmann Lars, Krahn Michael P

Abstract excerpt

Apical-basal polarity is an important characteristic of epithelia and Drosophila neural stem cells. The conserved Par complex, which consists of the atypical protein kinase C and the scaffold proteins Baz and Par6, is a key player in the establishment of apical-basal cell polarity. Membrane recruitment of Baz has been reported to be accomplished by several mechanisms, which might function in redundancy, to ensure...

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Identifiers

PMID: 29523893
DOI: 10.1007/s00018-018-2792-1
PMCID: PMC11105499

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