Article
On the mechanism of protein fold-switching by a molecular sensor.
Proteins - 1 Dec 2010
Stratton Margaret M, Loh Stewart N
Abstract excerpt
Alternate frame folding (AFF) is a mechanism by which conformational change can be engineered into a protein. The protein structure switches from the wild-type fold (N) to a circularly-permuted fold (N'), or vice versa, in response to a signaling event such as ligand binding. Despite the fact that the two native states have similar structures, their interconversion involves folding and unfolding of large parts of...
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