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Article

Glycobiology of syndecan-1 in bacterial infections.

Biochemical Society transactions - 17 Apr 2018

Aquino Rafael S, Teng Yvonne Hui-Fang, Park Pyong Woo

Abstract excerpt

Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis. Loss of Sdc1 in mice is a gain-of-function mutation that significantly decreases the susceptibility to several bacterial infections, suggesting that subversion of Sdc1 is an important virulence strategy. HS glycosaminoglycan (GAG) chains of...

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Identifiers

PMID: 29523771
DOI: 10.1042/BST20170395
PMCID: PMC6779160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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