<i>Candida albicans SET1</i> encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis

Abstract excerpt

Candida albicans causes diverse mucosal and systemic diseases. Although this versatility likely depends upon carefully co-ordinated gene expression, epigenetic regulation in C. albicans remains poorly characterized. Screening a genomic expression library, we identified C. albicans Set1p as an immunogenic protein with homology to a lysine histone methyltransferase of Saccharomyces cerevisiae. In this study, we...

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