The group A streptococcal collagen‐like protein‐1, Scl1 , mediates biofilm formation by targeting the extra domain A ‐containing variant of cellular fibronectin expressed in wounded tissue

Abstract excerpt

Wounds are known to serve as portals of entry for group A Streptococcus (GAS). Subsequent tissue colonization is mediated by interactions between GAS surface proteins and host extracellular matrix components. We recently reported that the streptococcal collagen-like protein-1, Scl1, selectively binds the cellular form of fibronectin (cFn) and also contributes to GAS biofilm formation on abiotic surfaces. One...

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