Scl1, the multifunctional adhesin of group A<i>Streptococcus</i>, selectively binds cellular fibronectin and laminin, and mediates pathogen internalization by human cells

Abstract excerpt

The streptococcal collagen-like protein-1, Scl1, is widely expressed by the well-recognized human pathogen group A Streptococcus (GAS). Screening of human ligands for binding to recombinant Scl1 identified cellular fibronectin and laminin as binding partners. Both ligands interacted with the globular domain of Scl1, which is also able to bind the low-density lipoprotein. Native Scl1 mediated GAS adherence to...

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