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Article

Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1

4 May 2016

Abstract excerpt

SPLUNC1 is an abundantly secreted innate immune protein in the mammalian respiratory tract that exerts bacteriostatic and antibiofilm effects, binds to lipopolysaccharide (LPS), and acts as a fluid-spreading surfactant. Here, we unravel the structural elements essential for the surfactant and antimicrobial functions of human SPLUNC1 (short palate lung nasal epithelial clone 1). A unique α-helix (α4) that extends...

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PMID: 27145151
DOI: 10.1021/acs.biochem.6b00271

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