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Article

Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection.

Scientific reports - 30 Mar 2022

Kim So Young, Gupta Purva, Johns Scott C, Zuniga Elina I, Teijaro John R, Fuster Mark M

Abstract excerpt

Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells via Ndst1f/f CD11cCre + mutation, which inhibits HS sulfation in a major antigen presenting cell population, reduces lung inflammation by A/Puerto Rico/8/1934(H1N1) influenza...

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Identifiers

PMID: 35354833
DOI: 10.1038/s41598-022-09197-7
PMCID: PMC8968721

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