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Article

Site-specific recombination in the replication terminus region of Escherichia coli: functional replacement of dif.

The EMBO journal - 3 Apr 1995

Leslie N R, Sherratt D J

Abstract excerpt

The replication terminus region of the Escherichia coli chromosome encodes a locus, dif, that is required for normal chromosome segregation at cell division. dif is a substrate for site-specific recombination catalysed by the related chromosomally encoded recombinases XerC and XerD. It has been proposed that this recombination converts chromosome multimers formed by homologous recombination back to monomers in...

Topics

Base Sequence
Cell Division
Chromosome Mapping
Chromosomes, Bacterial
DNA Replication
DNA, Bacterial
Escherichia coli
Genes, Bacterial
Genotype
Molecular Sequence Data
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

Recombination, Genetic

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 7729430
DOI: 10.1002/j.1460-2075.1995.tb07142.x
PMCID: PMC398243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7729430-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Site-specific recombination in the replication terminus region of Escherichia coli: functional replacement of dif.PMID 7729430Read ↗

Escherichia coli XerC recombinase is required for chromosomal segregation at cell division.Semantic proximity Read ↗

The dif resolvase locus of the Escherichia coli chromosome can be replaced by a 33-bp sequence, but function depends on location.Semantic proximity Read ↗

DNA degradation in the terminus region of resolvase mutants of Escherichia coli, and suppression of this degradation and the Dif phenotype by recD.Semantic proximity Read ↗

dif, a recA-independent recombination site in the terminus region of the chromosome of Escherichia coli.Semantic proximity Read ↗

FtsK-dependent and -independent pathways of Xer site-specific recombination.Semantic proximity Read ↗

Mobile element integration reveals a chromosome dimer resolution system in LegionellalesSemantic proximity Read ↗

Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome.Semantic proximity Read ↗

The dif/Xer recombination systems in proteobacteria.Semantic proximity Read ↗

C-terminal interactions between the XerC and XerD site-specific recombinases.Semantic proximity Read ↗

Cell division, guillotining of dimer chromosomes and SOS induction in resolution mutants (dif, xerC and xerD) of Escherichia coli.Semantic proximity Read ↗

Extent of the activity domain and possible roles of FtsK in the Escherichia coli chromosome terminus.Semantic proximity Read ↗

In vitro site-specific recombination mediated by the tyrosine recombinase XerA of Thermoplasma acidophilum.Semantic proximity Read ↗

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