Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.

doi:10.1016/j.ajhg.2025.05.006

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Article

Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.

American journal of human genetics - 3 Jul 2025

Thompson Emma E, Zhong Xiaoyuan, Carbonetto Peter, Morin Andréanne, Willwerscheid Jason, Visness Cynthia M, Bacharier Leonard B, Kattan Meyer, O'Connor George T, Rivera-Spoljaric Katherine, Wood Robert A, Gold Diane R, Khurana Hershey Gurjit K, Johnson Christine C, Miller Rachel L, Seroogy Christine M, Zoratti Edward M, Gergen Peter J, Levin Albert M, Altman Matthew C, Hartert Tina, Stephens Matthew, Jackson Daniel J, Gern James E, McKennan Christopher G, Ober Carole

Abstract excerpt

Asthma is a common respiratory disease, with contributions from both genes and the environment and significant heterogeneity in underlying endotypes; yet, little is known about the relative contributions of each to these endotypes. To address this gap, we used nasal mucosal cell DNA methylation (DNAm) and gene expression and genotypes for 284 children in the Urban Environment and Childhood Asthma (URECA) birth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40614707
DOI: 10.1016/j.ajhg.2025.05.006
PMCID: PMC12256822

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