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Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease.

Neurobiology of aging - 1 Aug 2012

Giambattistelli Federica, Bucossi Serena, Salustri Carlo, Panetta Valentina, Mariani Stefania, Siotto Mariacristina, Ventriglia Mariacarla, Vernieri Fabrizio, Dell'acqua Maria Luisa, Cassetta Emanuele, Rossini Paolo Maria, Squitti Rosanna

Abstract excerpt

It is now accepted that transition metals, such as iron and copper, are involved in the pathogenesis of the Alzheimer's disease (AD) through their participation in toxic oxidative phenomena. In this context, hemochromatosis (Hfe) and transferrin (Tf) genes are of particular importance, since they play a key role in iron homeostasis. Also, signs of liver distress which accompany metal dysmetabolisms have been...

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PMID: 21514009
DOI: 10.1016/j.neurobiolaging.2011.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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