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Article

Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population.

Journal of Alzheimer's disease : JAD - 1 May 2008

Percy Maire, Moalem Sharon, Garcia Angeles, Somerville Martin J, Hicks Mark, Andrews David, Azad Azar, Schwarz Peter, Beheshti Zavareh Reza, Birkan Rivka, Choo Clara, Chow Vinca, Dhaliwal Sandeep, Duda Victoria, Kupferschmidt Anthony L, Lam Kyla, Lightman Deborah, Machalek Karolina, Mar Wanna, Nguyen Frank, Rytwinski Piotr J, Svara Erin, Tran Maithy, Wheeler Kathleen, Yeung Lisa, Zanibbi Katherine, Zener Rebecca, Ziraldo Melissa, Freedman Morris

Abstract excerpt

Dysregulation of iron homeostasis is implicated in Alzheimer's disease (AD). In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in a...

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Identifiers

PMID: 18525129
DOI: 10.3233/jad-2008-14107

Genes

APOE
HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18525129-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population.PMID 18525129Read ↗

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