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Article

Blood HER2 and Uromodulin as Causal Mediators of CKD.

Journal of the American Society of Nephrology : JASN - 1 Apr 2018

Sjaarda Jennifer, Gerstein Hertzel C, Yusuf Salim, Treleaven Darin, Walsh Michael, Mann Johannes F E, Hess Sibylle, Paré Guillaume

Abstract excerpt

Many biomarkers have been epidemiologically linked with CKD; however, the possibility that such associations are due to reverse causation or confounding limits the utility of these biomarkers. To overcome this limitation, we used a Mendelian randomization (MR) approach to identify causal mediators of CKD. We performed MR by first identifying genetic determinants of 227 serum protein biomarkers assayed in 4147...

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Identifiers

PMID: 29511113
DOI: 10.1681/ASN.2017070812
PMCID: PMC5875953

Genes

ACE
UMOD
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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