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Mendelian randomization study supports the causal association between serum cystatin C and risk of diabetic nephropathy

17 Nov 2022

Abstract excerpt

Aims Cystatin C, an inhibitor of cysteine protease, has been used as a biomarker for estimating glomerular filtration rate. However, the causal relation between cystatin C and diabetic nephropathy remains uncertain. Methods We assessed the causal effect of cystatin C together with other five serum biomarkers including KIM-1, GDF-15, TBIL, uric acid, and Scr on diabetic nephropathy by Mendelian randomization (MR)...

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PMID: 36482996
DOI: 10.3389/fendo.2022.1043174

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