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Article

Mixed modeling of meta-analysis P-values (MixMAP) suggests multiple novel gene loci for low density lipoprotein cholesterol.

PloS one - 1 Jan 2013

Foulkes Andrea S, Matthews Gregory J, Das Ujjwal, Ferguson Jane F, Lin Rongheng, Reilly Muredach P

Abstract excerpt

Informing missing heritability for complex disease will likely require leveraging information across multiple SNPs within a gene region simultaneously to characterize gene and locus-level contributions to disease phenotypes. To this aim, we introduce a novel strategy, termed Mixed modeling of Meta-Analysis P-values (MixMAP), that draws on a principled statistical modeling framework and the vast array of summary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23405096
DOI: 10.1371/journal.pone.0054812
PMCID: PMC3566142

Genes

APOH
CDK6
GAB2
GAD2
NPC1
PPARD
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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