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Article

Item-level analyses reveal genetic heterogeneity in neuroticism.

Nature communications - 2 Mar 2018

Nagel Mats, Watanabe Kyoko, Stringer Sven, Posthuma Danielle, van der Sluis Sophie

Abstract excerpt

Genome-wide association studies (GWAS) of psychological traits are generally conducted on (dichotomized) sums of items or symptoms (e.g., case-control status), and not on the individual items or symptoms themselves. We conduct large-scale GWAS on 12 neuroticism items and observe notable and replicable variation in genetic signal between items. Within samples, genetic correlations among the items range between...

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Identifiers

PMID: 29500382
DOI: 10.1038/s41467-018-03242-8
PMCID: PMC5834468

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Source receipt: pubmed, retrieved 7 Sept 2026.

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