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Article

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression.

Nature human behaviour - 1 Oct 2021

Thorp Jackson G, Campos Adrian I, Grotzinger Andrew D, Gerring Zachary F, An Jiyuan, Ong Jue-Sheng, Wang Wei, Shringarpure Suyash, Byrne Enda M, MacGregor Stuart, Martin Nicholas G, Medland Sarah E, Middeldorp Christel M, Derks Eske M

Abstract excerpt

Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause considerable burden worldwide. Here we use factor analysis and genomic structural equation modelling to investigate the genetic factor structure underlying 28 items assessing depression, anxiety and neuroticism, a closely related personality trait. Symptoms of depression and anxiety loaded on two distinct, although highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33859377
DOI: 10.1038/s41562-021-01094-9

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