Article
Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.
Behavior genetics - 1 Jul 2014
van den Berg Stéphanie M, de Moor Marleen H M, McGue Matt, Pettersson Erik, Terracciano Antonio, Verweij Karin J H, Amin Najaf, Derringer Jaime, Esko Tõnu, van Grootheest Gerard, Hansell Narelle K, Huffman Jennifer, Konte Bettina, Lahti Jari, Luciano Michelle, Matteson Lindsay K, Viktorin Alexander, Wouda Jasper, Agrawal Arpana, Allik Jüri, Bierut Laura, Broms Ulla, Campbell Harry, Smith George Davey, Eriksson Johan G, Ferrucci Luigi, Franke Barbera, Fox Jean-Paul, de Geus Eco J C, Giegling Ina, Gow Alan J, Grucza Richard, Hartmann Annette M, Heath Andrew C, Heikkilä Kauko, Iacono William G, Janzing Joost, Jokela Markus, Kiemeney Lambertus, Lehtimäki Terho, Madden Pamela A F, Magnusson Patrik K E, Northstone Kate, Nutile Teresa, Ouwens Klaasjan G, Palotie Aarno, Pattie Alison, Pesonen Anu-Katriina, Polasek Ozren, Pulkkinen Lea, Pulkki-Råback Laura, Raitakari Olli T, Realo Anu, Rose Richard J, Ruggiero Daniela, Seppälä Ilkka, Slutske Wendy S, Smyth David C, Sorice Rossella, Starr John M, Sutin Angelina R, Tanaka Toshiko, Verhagen Josine, Vermeulen Sita, Vuoksimaa Eero, Widen Elisabeth, Willemsen Gonneke, Wright Margaret J, Zgaga Lina, Rujescu Dan, Metspalu Andres, Wilson James F, Ciullo Marina, Hayward Caroline, Rudan Igor, Deary Ian J, Räikkönen Katri, Arias Vasquez Alejandro, Costa Paul T, Keltikangas-Järvinen Liisa, van Duijn Cornelia M, Penninx Brenda W J H, Krueger Robert F, Evans David M, Kaprio Jaakko, Pedersen Nancy L, Martin Nicholas G, Boomsma Dorret I
Abstract excerpt
Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant...
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