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Article

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.

Genes & development - 1 Feb 2018

Finci Lorenzo I, Zhang Xiaofeng, Huang Xiuliang, Zhou Qiang, Tsai Jennifer, Teng Teng, Agrawal Anant, Chan Betty, Irwin Sean, Karr Craig, Cook Andrew, Zhu Ping, Reynolds Dominic, Smith Peter G, Fekkes Peter, Buonamici Silvia, Larsen Nicholas A

Abstract excerpt

Somatic mutations in spliceosome proteins lead to dysregulated RNA splicing and are observed in a variety of cancers. These genetic aberrations may offer a potential intervention point for targeted therapeutics. SF3B1, part of the U2 small nuclear RNP (snRNP), is targeted by splicing modulators, including E7107, the first to enter clinical trials, and, more recently, H3B-8800. Modulating splicing represents a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29491137
DOI: 10.1101/gad.311043.117
PMCID: PMC5859971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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