Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.

doi:10.1007/s00401-023-02566-0

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Article

Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.

Acta neuropathologica - 1 May 2023

Goddard Jack, Castle Jemma, Southworth Emily, Fletcher Anya, Crosier Stephen, Martin-Guerrero Idoia, García-Ariza Miguel, Navajas Aurora, Masliah-Planchon Julien, Bourdeaut Franck, Dufour Christelle, Ayrault Olivier, Goschzik Tobias, Pietsch Torsten, Sill Martin, Pfister Stefan M, Rutkowski Stefan, Richardson Stacey, Hill Rebecca M, Williamson Daniel, Bailey Simon, Schwalbe Edward C, Clifford Steven C, Hicks Debbie

Abstract excerpt

Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MBGrp4 molecular substructures have been identified (e.g. subgroups/cytogenetics/mutations), however their inter-relationships and potential to improve clinical sub-classification and risk-stratification remain undefined. We comprehensively characterised the...

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Identifiers

PMID: 37014508
DOI: 10.1007/s00401-023-02566-0
PMCID: PMC10119222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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