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Article

Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions.

Anticancer research - 1 May 2022

Sursal Tolga, Ronecker Jennifer S, Dicpinigaitis Alis J, Mohan Avinash L, Tobias Michael E, Gandhi Chirag D, Jhanwar-Uniyal Meena

Abstract excerpt

Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor. Recent genetic, epigenetic, and transcriptomic analyses have classified MB into three subgroups, Wingless Type (WNT), Sonic Hedgehog (SHH), and non-WNT/non-SHH (originally termed Group 3 and Group 4), with discrete patient profiles and prognoses. WNT is the least common subgroup with the best prognosis, characterized by nuclear...

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Gene Expression Profiling
Cerebellar Neoplasms
Child
Chromosome Aberrations
Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hedgehog Signaling Pathway Studies

Medulloblastoma

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PMID: 35489737
DOI: 10.21873/anticanres.15703

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