Article

Phosphorylation at S345 Converts HIF-2α from a Transcription Factor to an RNA binding protein

2026-04-30

Abstract excerpt

Oxygen sensing and adaptation are vital for metazoan survival. At the cellular level the response to hypoxia is characterised by a switch in transcriptional programming, primarily mediated by hypoxia-inducible factors (HIFs). HIFs comprise an obligatory heterodimer between an oxygen-sensitive HIF-α subunit and an oxygen-insensitive HIF-1β subunit, which together regulate gene expression in response to hypoxia. Amo...

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Literature Corpus work: 4f32d0e1-fdc6-54e8-9a6c-a9b3acf478e4
DOI: 10.64898/2026.04.28.721420

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