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Article

Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.

The Journal of biological chemistry - 20 Apr 2012

Obeid Samra, Welte Wolfram, Diederichs Kay, Marx Andreas

Abstract excerpt

Cleavage of the N-glycosidic bond that connects the nucleobase to the backbone in DNA leads to abasic sites, the most frequent lesion under physiological conditions. Several DNA polymerases preferentially incorporate an A opposite this lesion, a phenomenon termed "A-rule." Accordingly, KlenTaq, the large fragment of Thermus aquaticus DNA polymerase I, incorporates a nucleotide opposite an abasic site with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22318723
DOI: 10.1074/jbc.M111.334904
PMCID: PMC3340134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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