Article
NSAID use and somatic exomic mutations in Barrett's esophagus.
Genome medicine - 27 Feb 2018
Galipeau Patricia C, Oman Kenji M, Paulson Thomas G, Sanchez Carissa A, Zhang Qing, Marty Jerry A, Delrow Jeffrey J, Kuhner Mary K, Vaughan Thomas L, Reid Brian J, Li Xiaohong
Abstract excerpt
BACKGROUND: Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett's esophagus (BE) and to lower the incidence and mortality of esophageal adenocarcinoma (EA). The esophagus is exposed to both intrinsic and extrinsic mutagens resulting from gastric reflux, chronic...
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