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Article

NSAIDs modulate clonal evolution in Barrett's esophagus.

PLoS genetics - 1 Jun 2013

Kostadinov Rumen L, Kuhner Mary K, Li Xiaohong, Sanchez Carissa A, Galipeau Patricia C, Paulson Thomas G, Sather Cassandra L, Srivastava Amitabh, Odze Robert D, Blount Patricia L, Vaughan Thomas L, Reid Brian J, Maley Carlo C

Abstract excerpt

Cancer is considered an outcome of decades-long clonal evolution fueled by acquisition of somatic genomic abnormalities (SGAs). Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce cancer risk, including risk of progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA). However, the cancer chemopreventive mechanisms of NSAIDs are not fully understood. We hypothesized that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23785299
DOI: 10.1371/journal.pgen.1003553
PMCID: PMC3681672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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