Article
Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2006
Chao Dennis L, Maley Carlo C, Wu Xifeng, Farrow Diana C, Galipeau Patricia C, Sanchez Carissa A, Paulson Thomas G, Rabinovitch Peter S, Reid Brian J, Spitz Margaret R, Vaughan Thomas L
Abstract excerpt
BACKGROUND: Defects in DNA damage recognition and repair have been associated with a wide variety of cancers. We conducted a prospective study to determine whether mutagen sensitivity, as determined by an in vitro assay, was associated with the future development of cancer in patients with Barrett's esophagus, which is associated with increased risk of progression to esophageal adenocarcinoma. METHODS: We...
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