Article

Systematic analysis of rare variants in mitochondrial function-associated genes for autosomal-dominant Parkinson’s disease in a Chinese population

2020-04-28

Abstract excerpt

<title>Abstract</title> <p>Background Mitochondrial dysfunction is involved in the pathogenicity of Parkinson’s disease (PD). However, the genetic roles of mitochondrial function-associated genes responsible for PD need to be replicated in different cohorts. Methods Whole-exome and Sanger sequencing were used to identify the genetic etiology of 400 autosomal dominant-inherited PD (ADPD) patients. Variants in si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 152818a1-56b7-5812-b7a6-428674e88686
DOI: 10.21203/rs.3.rs-23120/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic analysis of rare variants in mitochondrial function-associated genes for autosomal-dominant Parkinson’s disease in a Chinese populationDOI 10.21203/rs.3.rs-23120/v1Read

Gene4PD: a comprehensive genetic database of Parkinson's diseaseSemantic proximity Read

Recent advances in novel mutation genes of Parkinson's disease.Semantic proximity Read

Parkinson's Disease, Parkinsonisms, and Mitochondria: the Role of Nuclear and Mitochondrial DNA.Semantic proximity Read

The role of genetics in Parkinson's disease: a large cohort study in Chinese mainland population.Semantic proximity Read

Estimated genetics prevalence of early-onset Parkinson’s disease caused by<i>PRKN</i>mutationsSemantic proximity Read

Analysis of rare Parkinson’s disease variants in millions of peopleSemantic proximity Read

Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations.Semantic proximity Read

Novel ATP13A2 and PINK1 variants identified in Chinese patients with Parkinson's disease by whole-exome sequencing.Semantic proximity Read

Genetic analysis of PARK2 and PINK1 genes in Brazilian patients with early-onset Parkinson's disease.Semantic proximity Read

Genes associated with Parkinson syndrome.Semantic proximity Read

Genetic Analysis of Patients With Early-Onset Parkinson’s Disease in Eastern ChinaSemantic proximity Read

Reanalysis of genetic variants detected by next generation sequencing in Parkinson’s disease with two novel variantsSemantic proximity Read