Article
Mitochondrial genome variations are associated with amyotrophic lateral sclerosis in patients from mainland China.
Journal of neurology - 1 Feb 2022
Ni Jie, Liu Zhen, Yuan Yanchun, Li Wanzhen, Hu Yiting, Liu Pan, Hou Xiaorong, Zhu Xiangyu, Tang Xuxiong, Liang Mingyu, Zheng Siqi, Hou Xuan, Du Juan, Tang Jianguang, Jiang Hong, Shen Lu, Tang Beisha, Wang Junling
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder. Mitochondrial dysfunction is involved in the complex pathophysiology of ALS; however, the role of mitochondrial DNA (mtDNA) variants in ALS is poorly understood. We aimed to elucidate the role of mtDNA variants in the pathogenesis of ALS. METHODS: The mitochondrial haplogroups of 585 ALS patients and 371 healthy controls...
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