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Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity

4 Aug 2021

Abstract excerpt

Group 2 innate lymphoid cells (ILC2s) manifest tissue heterogeneity and are crucial modulators of regional immune responses. The molecular mechanisms regulating tissue ILC2 properties remain elusive. Here, we interrogate the signatures of ILC2s from five tissues at the transcriptome and epigenetic level. We have found that tissue microenvironment strongly shapes ILC2 identities. The intestine induces Aiolos +...

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PMID: 34349237
DOI: 10.1038/s41385-021-00431-5

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