Article

Epigenetic patient stratification reveals a sub-endotype of type 2 asthma with altered B-cell response

2025-09-02

Abstract excerpt

Despite biomarker-guided treatment strategies, clinical outcomes among patients with type 2 (T2)-high asthma remain heterogeneous, with some patients responding poorly to T2-targeted biologic therapies. We developed a contrastive machine learning method for patient stratification based on whole-blood DNA methylation (DNAm), applying it to pediatric asthma cohorts of Latino (discovery; n=1,016) and African American...

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Literature Corpus work: b10cb3eb-7452-5cc4-a193-144ac48bd001
DOI: 10.1101/2025.08.28.25334696

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